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Iridoid Glycosides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Cytochrome P450 (1) ERK (1) HBV (2) HCV (1) NF-κB (2) Parasite (2)
By Research Areas:	Cancer (3) Infection (3) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0914

Ajugol 1 Publications Verification	Parasite	Others
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

HY-N8046

Gardoside

Others Others

Gardoside is an iridoid glycoside that can be found in the roots of L. alba .
HY-N2712

6''-O-trans-Feruloylcatalpol

Others Others

6''-O-trans-Feruloylcatalpol is a natural iridoid glycoside compound .
HY-N11712

8-Dehydroxyshanzhiside

Others Others

8-Dehydroxyshanzhiside is an iridoid glycoside that can be isolated from Lamiophlomis rotata .

Gardoside	Others	Others
Gardoside is an iridoid glycoside that can be found in the roots of L. alba .

6''-O-trans-Feruloylcatalpol	Others	Others
6''-O-trans-Feruloylcatalpol is a natural iridoid glycoside compound .

8-Dehydroxyshanzhiside	Others	Others
8-Dehydroxyshanzhiside is an iridoid glycoside that can be isolated from Lamiophlomis rotata .

HY-133109

Trachelosiaside	Others	Others
Trachelosiaside is a natural organic compound belonging to the class of iridoid glycosides. Trachelosiaside is found in various plant species, especially in the roots of Trachelospermum jasminoides. Trachelosiaside has potential medicinal properties, such as anti-inflammatory, antioxidant, and anti-tumor effects. Trachelosiaside has industrial applications in the production of food supplements, cosmetics and pharmaceuticals.

HY-N0820

Catalpol Maximum Cited Publications 6 Publications Verification Catalpinoside	HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N5086

Picroside IV	HBV	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N9352

Cantleyoside

Others Others

Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper .
HY-N1206

Specioside

6-O-(E)-p-Coumaroylcatalpol

Specioside is a novel iridoid glycoside extracted from Catalpa speciosa Warder (Bignoniaceae) .
HY-N2015

Hastatoside

Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .
HY-N0409

Picroside III

Others Inflammation/Immunology

Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .
HY-N4221

6'-O-Cinnamoyl harpagide

Others Others

6'-O-Cinnamoyl harpagide is an iridoid glycoside isolated from the roots of Scrophularia ningpoensis .

Cantleyoside	Others	Others
Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper .

Specioside 6-O-(E)-p-Coumaroylcatalpol
Specioside is a novel iridoid glycoside extracted from Catalpa speciosa Warder (Bignoniaceae) .

Hastatoside
Hastatoside is an iridoid glycoside that is isolated from Verbena officinalis and has a role in promoting sleep .

Picroside III	Others	Inflammation/Immunology
Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .

6'-O-Cinnamoyl harpagide	Others	Others
6'-O-Cinnamoyl harpagide is an iridoid glycoside isolated from the roots of Scrophularia ningpoensis .

HY-N11794

7-Ketologanin	Others	Others
7-Ketologanin is an iridoid glucoside. 7-Ketologanin can be isolated from the Stems of Viburnum erosum. 7-Ketologanin involves in biosynthetic pathway of oleuropein. Oleuropein, is a bioactive phenolic compound, modulates several oncogenic signalling pathways .

HY-N3839

epi-Vogeloside 7-epi-Vogeloside; Nervoside; Epivogeloside	Others	Others
epi-Vogeloside is a secoiridoid glycoside and a iridoid glucoside, which can be isolated from Lonicera japonica Thunb .

HY-N0512

Loganin 2 Publications Verification Loganoside	Apoptosis	Cancer
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.

HY-N12202

6′-O-β-D-Glucopyranosylphlorigidoside C	Others	Others
6′-O-β-D-Glucopyranosylphlorigidoside C (compound 1) is an iridoid glycoside that can be isolated from Lamiophlomis rotata .

HY-N6008

7-O-Methyl morroniside

Others Others

7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines .

7-O-Methyl morroniside	Others	Others
7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines .

HY-N0648

Monotropein	Others	Inflammation/Immunology
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model .

HY-N0494

Gentiopicroside 1 Publications Verification Gentiopicrin	Cytochrome P450 HCV	Inflammation/Immunology
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC₅₀ and a K_i of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.

HY-N2094

Genipin 1-β-D-gentiobioside Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside	Others	Inflammation/Immunology
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N6246

Asperulosidic Acid	NF-κB ERK	Inflammation/Immunology Cancer
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities . ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .

HY-N0397

Harpagide	Parasite	Infection Inflammation/Immunology
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-N12203

5-Deoxypulchelloside I

Others Others

5-Deoxypulchelloside I is a magnoside glycoside that can be isolated from the aerial parts of the Lamiaceae plant Eremostachys laciniata .

5-Deoxypulchelloside I	Others	Others
5-Deoxypulchelloside I is a magnoside glycoside that can be isolated from the aerial parts of the Lamiaceae plant Eremostachys laciniata .

Ajugol 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Source classification Other Diseases Scrophulariaceae Lactuca perennis Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields	Parasite
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC₅₀ of 31.8 μg/mL .

Gardoside	Iridoids Classification of Application Fields Terpenoids Source classification Other Diseases Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields	Others
Gardoside is an iridoid glycoside that can be found in the roots of L. alba .

6''-O-trans-Feruloylcatalpol	Structural Classification Iridoids Euryops arabicus Steud. ex Jaub. & Spach Terpenoids Labiatae Source classification Plants	Others
6''-O-trans-Feruloylcatalpol is a natural iridoid glycoside compound .

8-Dehydroxyshanzhiside	Structural Classification Ketones, Aldehydes, Acids Labiatae Source classification Plants Helenium radiatum (Less.) Bierner	Others
8-Dehydroxyshanzhiside is an iridoid glycoside that can be isolated from Lamiophlomis rotata .

Trachelosiaside	Apocynaceae Structural Classification Source classification Trachelospermum lucidum (D.Don) K.Schum. Coumarins Phenylpropanoids Plants	Others
Trachelosiaside is a natural organic compound belonging to the class of iridoid glycosides. Trachelosiaside is found in various plant species, especially in the roots of Trachelospermum jasminoides. Trachelosiaside has potential medicinal properties, such as anti-inflammatory, antioxidant, and anti-tumor effects. Trachelosiaside has industrial applications in the production of food supplements, cosmetics and pharmaceuticals.

Catalpol Maximum Cited Publications 6 Publications Verification Catalpinoside	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

Picroside IV	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Iridoids Terpenoids Phenols Scrophulariaceae Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	HBV
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

Cantleyoside	Iridoids Classification of Application Fields Terpenoids Dipsacaceae Source classification Other Diseases Plants Dipsacus asper Disease Research Fields	Others
Cantleyoside is a natiural iridoid glycoside that could be found in the Roots of Dipsacus asper .

Picroside III	Monophenols Iridoids Classification of Application Fields Terpenoids Source classification Phenols Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Inflammation/Immunology	Others
Picroside III is an iridoid glycoside isolated from Picrorhiza scrophulariiflora (PS), a traditional Chinese medicine .

6'-O-Cinnamoyl harpagide	Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Source classification Other Diseases Scrophulariaceae Plants Disease Research Fields	Others
6'-O-Cinnamoyl harpagide is an iridoid glycoside isolated from the roots of Scrophularia ningpoensis .

7-Ketologanin	Structural Classification Iridoids Terpenoids Source classification Viburnum erosum Thunb. Plants Adoxaceae	Others
7-Ketologanin is an iridoid glucoside. 7-Ketologanin can be isolated from the Stems of Viburnum erosum. 7-Ketologanin involves in biosynthetic pathway of oleuropein. Oleuropein, is a bioactive phenolic compound, modulates several oncogenic signalling pathways .

epi-Vogeloside 7-epi-Vogeloside; Nervoside; Epivogeloside	Structural Classification Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Source classification Plants	Others
epi-Vogeloside is a secoiridoid glycoside and a iridoid glucoside, which can be isolated from Lonicera japonica Thunb .

Loganin 2 Publications Verification Loganoside	Structural Classification Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects.

6′-O-β-D-Glucopyranosylphlorigidoside C	Structural Classification Iridoids Terpenoids Labiatae Source classification Plants Helenium radiatum (Less.) Bierner	Others
6′-O-β-D-Glucopyranosylphlorigidoside C (compound 1) is an iridoid glycoside that can be isolated from Lamiophlomis rotata .

7-O-Methyl morroniside	Iridoids Classification of Application Fields Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Other Diseases Plants Disease Research Fields	Others
7-O-Methyl morroniside is an iridoid glycoside (IG) extracted from Cornus officinalis fructus, used in many traditional Chinese medicines .

Monotropein	Iridoids Classification of Application Fields Terpenoids Pyrola calliantha H. Andr. Source classification Pyrolaceae Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	Others
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model .

Gentiopicroside 1 Publications Verification Gentiopicrin	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Inflammation/Immunology Disease Research Fields	Cytochrome P450 HCV
Gentiopicroside, a naturally occurring iridoid glycoside, inhibits P450 activity, with an IC₅₀ and a K_i of 61 µM and 22.8 µM for CYP2A6; Gentiopicroside has anti-inflammatoryand antioxidative effects.

Genipin 1-β-D-gentiobioside Genipin 1-gentiobioside; Genipin 1-β-gentiobioside; Genipin gentiobioside	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology	Others
Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities.

Catalposide	Other Terpenoids Catalpa ovata G. Don Monophenols Classification of Application Fields Terpenoids Source classification Phenols Plants Bignoniaceae Disease Research Fields Inflammation/Immunology	NF-κB
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

Asperulosidic Acid	Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	NF-κB ERK
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities . ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways .

Harpagide	Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Parasite
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

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Iridoid Glycosides

Inhibitors & Agonists

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